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The Anomaly Research Center (A.R.C.) faces unprecedented challenges when an excavation in Asheville, Tennessee, unleashes a deadly parasite that transforms humans into terrifying infected beings. With the infection spreading rapidly, survivors Vivian and Jaxon must navigate dangers including cunning Parasites, mindless Infected, and intelligent Ravagers. As they struggle to survive and find a cure, they face betrayal, loss, and unexpected alliances.