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Charlie and Blu, two highschool freshman, have their lives turned upside down when they find Fox, a runaway human-like fox experiment from the lab Blu's mom works at. Fox manages to escape the lab. But, when they return to the lab to rescue Fox's friends, Charlie and Blu are exposed to the same transformation and become a leopard and a wolf. Now they have to deal with their new forms and hide their secret from everyone, while hiding from an organization chasing them.