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The world changed when a parasite known as "Root of Dust" appeared. It invades the human nervous system, gradually taking control of both body and mind. Most of the infected are doomed to lose themselves and become monsters, while those infected are taken from their families and confined in SIREN research facilities. Olivia Anderson is one of the few who has learned to live in harmony with her parasite. But the deeper the host's emotional scars, the more terrifying the creature within becomes.